Dr. Dorothe Burggraf

1. Engel M, Endesfelder D, …, Burggraf D, …, Schloter M, Zu Castell W. Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome. PLoS One. 2017 Jul 13;12(7)

2. Subramanian DR, Gupta S, Burggraf D, …Ziegler-Heitbrock L, Brightling C, Parr DG. Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography. Eur Respir J. 2016 Jul;48(1):92-103

3. Hofer TP, Frankenberger M, Heimbeck I, Burggraf D, Wjst M, Wright AK, Kerscher M, Nährig S, Huber RM, Fischer R, Ziegler-Heitbrock L. Decreased expression of HLA-DQ and HLA-DR on cells of the monocytic lineage in cystic fibrosis. J Mol Med (Berl). 2014 Dec;92(12):1293-304.

4. Burggraf D, Heiss-Neumann M, Wjst M, Ziegler-Heitbrock L. Reference values for respiratory system resistance in adults. Accepted abstract ERS annual meeting 2012

5. Heiss-Neumann M, Burggraf D, Wjst M, Ziegler-Heitbrock L. Airway Resistance. Accepted abstract ERS annual meeting 2012

6. Ziegler-Heitbrock L, Burggraf D, Heiss-Neumann M, Wjst M. The EvA study: characteristics of the study population. Accepted abstract ERS annual meeting 2012

7. Ziegler-Heitbrock L, Frankenberger M, Heimbeck I,  Burggraf D, … Müller-Quernheim J, Prasse A. The EvA study: aims and strategy. ERJ 2012; 40:823-9.

8. Burggraf D, Vosko MR, Schubert M, Stassen JM, Hamann GF Different therapy options protecting microvasculature after experimental cerebral ischaemia and reperfusion. Thromb Haemost. 2010;103(5):891-900.

9. Burggraf D, Herzog F, Martens HK, Dichgans M, Haman GF. Combination Of Hypothermia With Thrombolysis With Rt-PA Reduces Haemorrhages In A Rat Model Of Experimental Stroke. Stroke 2009; 40(4); E222.

10. Burk J, Burggraf D, Vosko M, Dichgans M, Hamann GF. Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. Brain Res. 2008;1226: 248-55.

11. Burggraf D, Trinkl A, Burk J, Martens HK, Dichgans M, Hamann GF. Vascular Integrin immunoreactivity is selectively lost on capillaries during rat focal cerebral ischemia and reperfusion. Brain Res. 2008; 1189C: 189-197.

12. Burggraf D, Burk J, Schuhmacher S, Vosko MR, Dichgans M, Hamann GF. TIMP1 protects mouse brain from ischemic damage of the BBB. Accepted abstract Stroke Conference 2008

13. Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Effects of hypothermia on focal cerebral ischemia in plasminogen knockout mice. Accepted abstract Stroke Conference 2008

14. Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Hypothermia strengths inhibitors of matrix degrading proteases following experimental focal cerebral ischemia in mice. Abstract Brain 07

15. Burggraf D, Martens HK, Dichgans M, Hamann GF, MMP induction and inhibition at different doses of recombinant tissue plasminogen activator following experimental stroke. Thrombosis and Haemostasis 2007; 98(5): 963-9.

16. Burggraf D, Schuhmacher S, Dichgans M, Hamann GF. Increasing doses of rt-PA reduce MMP3-activity following experimental focal cerebral ischemia. Abstract Brain 07

17. Burggraf D, Schubert M, Vosko M, Dichgans M, Hamann GF. Microplasmin reduces dose-dependently microvascular basal lamina damage in experimental focal cerebral ischemia. Abstract Brain07

18. Burggraf D, Martens HK, Dichgans M, Hamann GF. rt-PA causes a dose-dependent increase in the extravasation of cellular and non-cellular blood elements after focal cerebral ischemia. Brain Res. 2007; 1164: 55-62.

19. Burggraf D, Trinkl A, Dichgans M, Hamann GF. Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol Dis. 2007; 25(3): 506-13.

20. Khandoga A, Kessler JS, Hanschen M, Khandoga AG, Burggraf D, Reichel C, Hamann GF, Enders G, Krombach F. Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver J Leukoc Biol. 2006; 79(6): 1295-305.

21. Vosko MR, Burggraf D, Liebetrau M, Wunderlich N, Jäger G, Gröger M, Plesnila N, Hamann GF. Influence of the duration of ischemia and reperfusion on infarct volume and microvascular damage in mice. Neurol Res. 2006; 28(2): 200-5.

22. Vosko MR, Liebetrau M, Trinkl A, Burggraf D, Jaeger G, Wunderlich N, Stassen JM, Hamann GF. Microplasmin reduces microvascular damage and blood-brain barrier disruption following experimental stroke. Stroke 2005; 36 (2): 472-472

23. Burggraf D, Martens HK, Liebetrau M, Vosko MR, Dichgans M, Hamann GF. A new approach to reduce the number of animals used in experimental focal cerebral ischemia models. Neurosci Lett. 2005; 386(2): 88-93.

24. Burggraf D, Liebetrau M, Martens HK, Wunderlich N, Jäger G, Dichgans M, Hamann GF. Matrix metalloproteinase induction by EMMPRIN in experimental focal cerebral ischemia. Eur J Neurosci. 2005; 22(1): 273-7.

25. Liebetrau M, Burggraf D, Büscher C, Linz W, Hamann GF. Ramipril prevents extracellular matrix accumulation in cerebral microvessels. Neurol Res. 2005; 27(5): 477-82.

26. Liebetrau M, Martens H, Thomassen N, Burggraf D, Gabrijelcic-Geiger D, Lubisch W, Möller A, Hamann GF. Calpain inhibitor A-558693 in experimental focal cerebral ischemia in rats. Neurol Res. 2005; 27(5): 466-70.

27. Grobholz K, Burggraf D, Martens KH, Wunderlich N, Pichler M, Hamann FG. Recombinant tissue plasminogen activator attenuates basal lamina antigen loss after experimental focal cerebral ischemia. Neurol Res. 2005; 27(2): 212-7.

28. Liebetrau M, Burggraf D, Wunderlich N, Jäger G, Linz W, Hamann GF. ACE inhibition reduces activity of the plasminogen/plasmin and MMP systems in the brain of spontaneous hypertensive stroke-prone rats. Neurosci Lett. 2005; 376(3): 205-9.

29. Burggraf D, Martens HK, Wunderlich N, Jäger G, Hamann GF. Rt-PA causes a significant increase in endogenous u-PA during experimental focal cerebral ischemia. Eur J Neurosci. 2004; 20(11): 2903-8.

30. Liebetrau M, Burggraf D, Martens HK, Pichler M, Hamann GF. Delayed moderate hypothermia reduces calpain activity and breakdown of its substrate in experimental focal cerebral ischemia in rats. Neurosci Lett. 2004; 357(1): 17-20.

31. Hamann GF, Burggraf D, Martens HK, Liebetrau M, Jäger G, Wunderlich N, DeGeorgia M, Krieger DW. Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia. Stroke. 2004; 35(3): 764-9.

32. Vosko MR, Busch E, Burggraf D, Bültemeier G, Hamann GF. Microvascular basal lamina damage in thromboembolic stroke in a rat model. Neurosci Lett. 2003; 353(3): 217-20.

33. Hamann GF, Schröck H, Burggraf D, Wunderlich N, Liebetrau M, Kuschinsky W. Microvascular Basal lamina damage after embolic stroke in the rat: relationship to cerebral blood flow. J Cereb Blood Flow Metab. 2003; 23(11): 1293-7.

34. Muellner A, Benz M, Kloss CU, Mautes A, Burggraf D, Hamann GF. Microvascular basal lamina antigen loss after traumatic brain injury in the rat. J Neurotrauma. 2003; 20(8): 745-54.

35. Burggraf D, Martens HK, Jäger G, Hamann GF. Recombinant human tissue plasminogen activator protects the basal lamina in experimental focal cerebral ischemia. Thromb Haemost. 2003; 89(6): 1072-80.

36. Loy M, Burggraf D, Martens KH, Liebetrau M, Wunderlich N, Bültemeier G, Nemori R, Hamann GF. A gelatin in situ-overlay technique localizes brain matrix metalloproteinase activity in experimental focal cerebral ischemia. J Neurosci Methods. 2002; 116(2): 125-33.

37. Hamann GF, Liebetrau M, Martens H, Burggraf D, Kloss CU, Bültemeier G, Wunderlich N, Jäger G, Pfefferkorn T. Microvascular basal lamina injury after experimental focal cerebral ischemia and reperfusion in the rat. J Cereb Blood Flow Metab. 2002; 22(5): 526-33.

38. Hamann GF, Liebetrau M, Martens H, Burggraf D, Kloss CU, Bültemeier G, Wunderlich N, Jäger G, Pfefferkorn T. Microvascular basal lamina injury after experimental focal cerebral ischemia and reperfusion in the rat. J Cereb Blood Flow Metab. 2002; 22(5): 526-33.

39. Burggraf D, Weber G, Lottspeich F. Free flow-isoelectric focusing of human cellular lysates as sample preparation for protein analysis. Electrophoresis. 1995; 16(6): 1010-5.

40. Burggraf D, Lottspeich F. The further construction of the two-dimensional database of common human proteins. Electrophoresis. 1995;16(5): 831-40.

41. Burggraf D, Andersson K, Eckerskorn C, Lottspeich F. Towards a two-dimensional database of common human proteins. Electrophoresis. 1992; 13(9-10): 729-32.

Ausbildung

1985 – 1991 Studium der Chemie, LMU München, Diplom

1991 – 1995 Doktorarbeit, LMU München und MPI für Biochemie , Dr. rer. nat.

1996 – 2001 Studium der Betriebswissenschaften, Fernuniversität Hagen, Diplom

Beruf

1995 – 1996 Toplab GmbH, Produktentwicklerin

2000 – 2002 Postdoc, LMU Neurologie

2002 – 2009 Gruppenleiterin „Vaskuläre Schädigungen beim Schlaganfall“, Neurologie, LMU München

2009 – 2013 Projektmanagerin, Helmholtz Zentrum München

2013 – 2018 Leitung Fördermittelmanagement Deutsche Zentren für Lungen – und Diabetesforschung, Helmholtz Zentrum München

2019 – jetzt Leitung der Administration und Infrastruktur, Max-Planck-Institut für die Physik des Lichts, Erlangen

Sonstiges

2003 – 2012 Vorlesung Nervensystem und Verhalten, Blockpraktikum Neurologie, Betreuung Semester-, Diplom- und Doktorarbeiten

2003 – 2015 Editorial Review Arbeiten für Journal of Neurological Methods, Neurobiological Disease, Brain Research, Journal Vascular Research, Journal of Neurology, Cerebrovascular Disease