Optofluidic integration of hollow-core photonic crystal fibres

31.10.2012, 14:36

Newsletter 5

Liquid-filled hollow-core photonic crystal fibers (HC-PCFs) are perfect optofluidic channels, uniquely providing low-loss optical guidance in a liquid medium. The overlap between the fluid sample and the intense light field in the micron-sized core is many times greater than in conventional bio-analytical set-ups, facilitating highly-efficient photoactivation. We introduce an integrated analytical technology for photochemistry in which a HC-PCF nanoreactor is coupled through microfluidic circuitry to supplementary detectors. Applying a continuous flow through the fiber, we deliver the photochemical reaction products to a mass spectrometer in an online and rapid fashion. As proof of principle, the photolysis of vitamin B12 was studied. The observed reaction products were in excellent agreement with conventional methods. The small dimensions of both the HC-PCF core and the microfluidic circuit make the technique about 50× less sample- and time-consuming than cuvette-based approaches. The work is the result of an on-going collaboration with the Department of Chemistry at the University of Warwick (UK). In future work we plan to identify short-lived reaction products from photoactivated anticancer complexes in order to unravel their mechanism of action.


Contact: sarah.unterkofler(at)mpl.mpg(dot)de
Group: Russell Division
Reference: S. Unterkofler et al., Opt. Lett. 37, 1952-1954 (2012).