Molecular interactions at a biosensor interface

We are interested in developing biosensing assays for clinically relevant biomarkers as well as for single cell analysis. Surface functionalization procedures of glass microsphere cavities have been developed to conjugate various antibodies which are used as recognition elements for detection of various biomarkers. The microspheres will be integrated in devices similar to the one shown here, for multiplexed chip-scale detection of various biomarkers from cell culture and engineered tissue. Here we are collaborating with colleagues from medicine and biology to develop on-chip molecular diagnostic tools. Such microchip devices will use DNA nanotechnology for improving nucleic acid detection limits, will monitor cells in culture and engineered tissue, and will detect kidney biomarkers in urine samples.