Abstract of IMPRS project(s)

Our laboratory studies the mechanical behavior of cells, including cell adhesion, spreading, deformation, motion, migration, invasion, stiffness, viscosity, force generation and mechano-transduction. These mechanical processes are essential for many cellular functions. Abnormal cell mechanical behavior is often associated with severe disorders such as cancer or cardiovascular diseases. We collaborate with research groups worldwide to develop novel technologies that enable us to measure or apply small forces (in the pico-Newton range) and deformations (in the low nano-meter range) that are relevant for cell mechanical functions. We use these technologies to study the behavior of cells on nano-structured biomaterials, cancer cell migration in 3-dimensional biopolymer networks, or the biochemistry of adhesion proteins.

Publications L. A. Lautscham, C. Y. Lin, V. Auernheimer, C. A. Naumann, W. H. Goldmann, B. Fabry, Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate, Biomaterials, , , (2014)

J. Ivanovska, A. Tregubova, V. Mahadevan, S. Chakilam, M. Gandesiri, N. Benderska, B. Ettle, A. Hartmann, S. Söder, E. Ziesché, T. Fischer, L. Lautscham, B. Fabry, G. Segerer, A. Gohla, R. Schneider-Stock, Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis, The International Journal of Biochemistry & Cell Biology , , , (2013)

S. Münster, L.M. Jawerth, B. Fabry, and D.A. Weitz, Structure and mechanics of fibrin clots formed under mechanical perturbation, Journal of Thrombosis and Haemostasis, 11(3), 557-560, (2013)

S. Münster, B. Fabry, A Simplified Implementation of the Bubble Analysis of Biopolymer Network Pores, Biophysical Journal, 104(12), 2774-5, (2013)

S. Münster, L.M. Jawerth, B.A. Leslie, J.I. Weitz, B. Fabry, and D. A. Weitz., Strain history dependence of the nonlinear stress response of fibrin and collagen networks, PNAS, 110(30), 12197-12202, (2013)

N. Bonakdar, J. Luczak, L. Lautscham, M. Czonstke, T.M. Koch, A. Mainka, T. Jungbauer, W. H. Goldmann, R. Schröder, B. Fabry, Biomechanical characterization of a desminopathy in primary human myoblasts, Biochem Biophys Res Commun., , , (2012)

T.M. Koch, S. Münster, N. Bonakdar, J.P. Butler., B. Fabry, 3D Traction Forces in Cancer Cell Invasion , PLoS One, 7(3), e33476, (2012)

Y.-H. Lin, D. E. Minner, L. Lautscham, A. Schoenborn, W. Goldmann, B. Fabry, C. A. Naumann, Cellular Mechano-Stimulation by Adjusting the Viscous Drag of Cell-Substrate Linkers in Biomembrane-Mimicking Cell Substrates, Biophysical Journal, 102, , (2012)

J. Breyer, J. Samarin, M. Rehm, L. Lautscham, B. Fabry, M. Goppelt-Struebe, Inhibition of Rho kinases increases directional motility of microvascular endothelial cells, Biochemical Pharmacology, 83, 616-626, (2011)

L.M. Jawerth*, S. Münster,* D.A Vader, B. Fabry, D.A. Weitz, A Blind Spot in Confocal Reflection Microscopy: The Dependence of Fiber Brightness on Fiber Angle in Imaging Biopolymer Networks, Biophysical Journal, 98(3), L1-L3, (2010)

C. Metzner, M. Sajitz-Hermstein, M. Schmidberger, B. Fabry, Noise and critical phenomena in biochemical signaling cycles at small molecule numbers, Phys. Rev. E, 80, 021915, (2009)

W. Mickel*, S. Münster,* L.M. Jawerth, D.A. Vader, D.A. Weitz, A.P. Sheppard, K. Mecke, B. Fabry, G. Schroeder-Turk, Robust Pore Size Analysis of Filamentous Networks from Three-Dimensional Confocal Microscopy, Biophysical Journal, 95(12), 6072-80, (2008)