Welcome to the Sandoghdar Division
at the Max Planck Institute for the Science of Light

    • Cryogenic localization microscopy
    • Two distant molecules communicate via single photons
    • iSCAT visualizes nanoconfinement in lipid bilayers
    • Nanopipette electrostatic trap
    • Label-free Single Protein Detection
    • Our move from Zurich
    • Single molecules in a dielectric nanoguide
  • The research of our group aims to advance experimental and theoretical mastery of light-matter interaction at the nanometer scale and to achieve the same degree of control and finesse that is known from the gas-phase quantum optics in the condensed phase. To do this, we combine concepts from quantum optics, laser spectroscopy, cryogenics, optical imaging, scanning probe technology and nanofluidics. In this endeavour, we have addressed a wide spectrum of scientific questions, ranging from quantum optics to biophysics. For more information, please consult our research website and our list of publications.

    Our biophotonics research is featured at Biophysical Society TV

    The review of the Symposium "Systems Neuroscience" is online



New article in the Journal of Visualized Experiments (JoVE): Label-Free Imaging of Single Proteins Secreted from Living Cells via iSCAT Microscopy

We present a protocol for the real-time optical detection of single unlabeled proteins as they are secreted from living cells. This is based on interferometric scattering (iSCAT) microscopy, which can be applied to a variety of...[more]


New publication submitted: Interferometric scattering microscopy reveals microsecond nanoscopic protein motion on a live cell membrane

Much of the biological functions of a cell are dictated by the intricate motion of proteins within its membrane over a spatial range of nanometers to tens of micrometers and time intervals of microseconds to minutes. While this...[more]


William Hamlyn wins poster prize at ICAP 2018

Congratulations! At ICAP 2018 William Hamlyn won the Nature Physics Reviews prize for his poster entitled "Atom-light interactions in thermal Rubidium vapours confined to a volume less than λ3". Download...[more]


New publication in Nano Letters: High-Speed Microscopy of Diffusion in Pore-Spanning Lipid Membranes

Pore-spanning membranes (PSMs) provide a highly attractive model system for investigating fundamental processes in lipid bilayers. We measure and compare lipid diffusion in the supported and suspended regions of PSMs prepared on...[more]